ANTHCLOSA (Closantel) is antiparasitic salicylanilides.
Salicylanilides are proton ionophores that act as uncouplers specific mitochondrial oxidative phosphorylation disrupting energy metabolism of the parasite.
- ANTHCLOSA is well tolerated by
- Cattle
- Sheep
- ANTHCLOSA has
- Fasciolicide activity as it is effective on both immature and mature Fasciola species
- It also has a powerful Effective against larva of flies causing specific-myiasis like Oestrus ovis and Hypoderma bovis.
- Also Has a Nematicide activity against certian economically important hematophagus nematodes of ruminants as Haemonchus contortus, H. placei, Ostertagia spp., Trichostrongylus spp., Bunomostomum phelbotmus, Oesphagostomum spp., and Chaberia ovina).
- Some studies domenstrates closantel efficacy on mites producing mange in cattle and sheep.
- Its effect is due to its many advantages
As it is has a high safety margin up to 4 times the recommended dose.
Unlike other commonly used fasciolicidal drug. Closantel-resistant Fasciola is not reported in Egypt and worldwide except in few cases only.
after injection of Closantel it bounds with plasma albumin, its terminal half life (~15 days), its residues may last its efficacy in cattle up to 60 days.
- Closantel Rout of administration is subcutaneously With weight dependent dose
- As Cattle & sheep less than 200 kg need 1 ml of product per 10kg of animal’s body weight
- And which is over 200kg needs 0.5-1 ml of product per 10 kg of animal’s body weight
ANTHCLOSA manufactured by ARABCOMED for first pharma egypt company for commercial use in Egypt And Also for exporting .