DISULPHA

Each 100 ml contains:

Sulphadimethoxine Trimethoprim

Properties

Sultadimethoxine is a long-acting sulphonamide.

Sulphohamides inhibit the DNA-synthesis or Sensiive protozoa and qrganisms by inhibition of the folic acid synthesis.

Sulfonamides inhibit DOn Gram-positive and gram-negative bacteria, Nocardia, Actinomyces spp, and some proozoa Such as coccidia ang Toxoplasma spp They compete with para-amino benzoic acid in the synthesis of dihydrofolate, which is an essential co-factor in the synthesis of DNA. Product has a coccidiocide effect by elimination of the schizogony. and trimethoprim inhibits tne enzyme dihydrofolate reductase which converts dihydrofolic acid into tetrahydrofolic acid. The best combination in vivo is 5:1 (SMX:TMP).

The combination of the two compounds act synergistically and bactericidally. The spectrum is broadened by combining the wo compounds and the development of resistance is slower down. combination has a broad and bactericidal action against many gram-posittve and gram-negative aerobic bacteria, a large proportion of anaerobic bacteria, chlamydia, and protozoa.

Indications

Recommended in cattle for the treatrment of bovine respiratory disease complex (shipping

fever complex) and bacterial pneumonia associated with Pasteurella spp.

 senitive to Sulfadimethoxine; necrotic pododermatitis (foot rot) and calf diphtheria caused by

Fusobacterium necrophorum, sensitive to sulfadimethoxine.

 Target species:

Cattle

Dosage &administration:

Route of administration: By intramuscular injection

For active ingredients

Cattle: (80 mg sulphadimethoxine +8 mgtrimethoprim)/ kg .b.wt

For whole product

 Cattle: 4 ml/ 10 kg .b.wt.

Warnings and precautions

The possibility of potential damage to the kidney or liver or hematopoietic system should be

considered

-Use of the product should be based on susceptibility testing of the  bacteria isolated from the animal .If this is not possible, therapy should be based on local (regional, farm level) epidemiological information about susceptibility of the target bacteria.